I have seen that some people have theories that Alex Wesker could possiably be a women. After all "Alex" is a unisex name, so it's not confined to one gender.
On another note, HUNK in RE:ORC seems to be very much a male, but we also dont know for sure that Alex Wesker is HUNK, its only a suspition.
We aslo have only (officially) met one of the 13 Wesker childern, Albert Wesker. I do really hope we get insites as to what the other ones were like, or if any of them are still alive. If there is one thing you can count on in RE, it's that it takes more than one game to kill a character lol . I think with RE6 bringing Albert Weker's son to light, that we will learn more about Project W in the near future.
Not really sure what to think about this, and im welcome to anyone's ideas, as long as you provide some sort of evidence for your claims! haha