The Hunter α (development code: "MA-121") can be regarded as the first fully functional and marketable built-from-scratch B.O.W. produced by Umbrella. It was created by injecting reptilian DNA into a human embryo and administering the t-Virus as a bonding agent. The MA-121α went through intensive research and development at the underground lab in Raccoon City.
In the midst of the t-Virus outbreak in Raccoon Forest, a number of α models were released by a resurrected James Marcus to eliminate Rebecca Chambers and Billy Coen as they combed the Umbrella Research Center. There were also a good deal of Alphas still being stored in the Arklay Laboratory, where it appeared that they took to hunting across the estate with at least one of them reaching the estate and slashing at wallpaper, evident in one of the rooms. Although highly reliable, Umbrella continued to make modifications to its specific design, resulting in the Hunter R model.
However, despite Umbrella's newer prototypes, the α model proved to be the most well-developed base, and the mass-production Hunter model stemmed from the α line. An example of the mass-production model's usage was in 2004, during the Terragrigia Panic; the terrorist group, Veltro deployed a massive number of these Hunters into Terragrigia. They were destroyed along with the city by the Regia Solis. In 2005, several Hunters were encountered by the BSAA on board the Queen Zenobia and at an abandoned Veltro base, along with their enhanced t-Abyss counterparts, the Farfarellos.