Jessica Trevor was the wife of George Trevor and mother of Lisa Trevor. Jessica and Lisa were abducted by Oswell E. Spencer, co-founder of the Umbrella Corporation, and brought to the Arklay Laboratory due to the fact that both were aware of George's involvement with Spencer and his newly created mansion in the Arklay Mountains. Jessica became a victim of viral testing at the hands of Spencer and the Arklay research team, who infected her with a "Type-A" variation of the Progenitor virus. She wrote a final emotional note to her daughter, fearing the worst and plotting to escape the mansion with Lisa the next time they would be reunited.
However, before the note could get to Lisa, Jessica was killed by Umbrella because she displayed no reaction to the treatment.