The Verdugo were created by a fusion of human and insect DNA implanted with Plagas. Two Verdugo, presumably the only two in existence, served as Ramon Salazar's personal bodyguards. They concealed their mutated forms beneath voluminous Los Iluminados cloaks, with one wearing red and the other wearing black.
When Leon survived a booby trap in The castle, the diminutive master of the castle sent his red-cloaked Verdugo to personally kill the intruder. The Verdugo cornered Leon in the sewers under the castle, but the former Raccoon City Police officer managed to evade it. The black-cloaked Verdugo remained at Salazar's side, and eventually fused with its master and the Queen Plaga to fight Leon.