(Covers information from Anderson's universe)
This was a clone of Doctor Alexander Isaacs who took on a leading role in the Umbrella Corporation late in the Global T-Virus pandemic. Like the real Dr. Isaacs, he is a religious fanatic who wants to cleanse the earth of people and start anew with the Umbrella employees, and is unaware of his identity as a clone. He is portrayed by Scottish actor Iain Glen.
As the extinction of humanity during the Global T-Virus pandemic fails to go according to plan, the Umbrella Corporation creates this clone of the real Doctor Alexander Isaacs to lead the effort to finish "cleansing" the world of humanity. This clone believes himself to be the real Isaacs, awoken early from stasis to finish the cleansing of humanity. During this effort, Isaacs encounters and kills several Alice clones who oppose his plans, cutting off their heads and storing them in a drawer in his tank.
Encounter with AliceEdit
In order to destroy the last human settlement, Isaacs sets out with three Undead armies led by Umbrella tanks to the ruins Raccoon City where the settlement is located in a tower. Inside of his tank, Isaacs keeps several prisoners who he attempts to indoctrinate to his fanatically religious views and who are terrified of him.
Along the way, Isaacs and his men encounter and capture Alice who had been rendered unconscious after attempting to steal an Umbrella motorcycle. Alice is shocked to see Isaacs, having believed him dead some time before. Alice quickly realizes that the Isaacs she killed was simply a clone and comes to believe that this was the real Isaacs. From Alice's comments, Isaacs realizes that she knows of the anti-virus and decides to force Alice to run behind his tank to force her to talk.
After a while, Isaacs learns that Alice has disappeared and sends his men on top of the tank to locate her. When Alice begins fighting his men, Isaacs climbs on top of the tank to battle Alice himself, proving to be a match for her. Alice eventually forces Isaacs to release her bindings, but he gains the upper hand in the fight. Spotting a motorcycle in a side compartment of the tank, Alice opens it, amusing Isaacs who knows she can't escape as she is not an authorized user of the motorcycle. In response, Alice cuts off Isaacs' hand and uses it to activate the motorcycle and escape. Isaacs' hand is then dropped to the ground where it is eaten by an Undead. Isaacs, in great pain, enters the tank where he has his men attempt to kill Alice with the tank's weapons, but they fail and she escapes. Isaacs' stump is bandaged and he warns Albert Wesker of the events.
Attack on the settlementEdit
Isaacs' army eventually reaches the human settlement in Raccoon City where he prepares to attack. To Isaacs' anger, his second tank is destroyed by a makeshift bomb made out of a gasoline barrel. Isaacs then orders the "bait" released and sends out one of the prisoners from his tank, chased by the Undead from his army. Isaacs watches as the woman races towards the front gate of the settlement with Claire Redfield and Doc desperately trying to save her while Alice drops another bomb on the Undead. When the woman is nearly at the gate, Isaacs has his men kill her with the tank's weapons and then blow open the gate. Isaacs watches in glee as the settlement's defenses are overrun by his Undead army. However, to his shock, Alice kills most of the Undead army by pouring waterfalls of ignited gasoline on them from the roof.
After killing most of Isaacs' army, Alice climbs onto his tank and pours gasoline inside. Realizing what's about to happen, Isaacs orders his men to close the vents, but too late as Alice ignites the gasoline with a flare. The ignited gasoline kills the tank crew, but Isaacs manages to escape out the back through the prisoner compartment. He then hides nearby and listens in as Alice discusses a mission into the Hive to get the anti-virus.
Leading an armyEdit
Desperate to stop Alice, Isaacs meets up with one of the other two Undead armies heading to the human settlement and tries to redirect it to defend the Hive. When the tank crew refuses, Isaacs murders them and takes control of the tank for himself. Isaacs leads the Undead army to the crater in Raccoon City, but loses control and crashes the tank at the bottom. Drawing the army's attention, Isaacs jumps from the tank and leads them on a charge towards the Hive.
Encounter with himself and deathEdit
Reaching the entrance to the Hive, Isaacs is shocked to find Alice with the real Doctor Alexander Isaacs. The Isaacs clone, created to believe that he is the original as all Umbrella clones are created to do, refuses to believe his original self's insistence that he is the clone. Enraged, the Isaacs clone attacks the original and stabs him multiple times, causing the original Isaacs life support system to fail and killing him. Pleased, the clone repeats that he is the real one to Alice before being attacked and killed by the Undead. Thanks to the clone's attack, Alice is able to release the anti-virus which kills the Undead army, including the ones attacking the Isaacs clone.
Like the original Isaacs, this clone was religious and desired to "cleanse" the Earth of humanity like the Great Flood. However, over time this Isaacs fanatically religious fervor turned him into an insane zealot who believed he was the holy instrument of God. He was also highly sadistic as shown by his treatment of the prisoners in his tank.
- Unlike the other Isaacs clone, this one truly believed himself to be Doctor Isaacs. The other appeared to serve a similar role to "Bad Rain" and the clones of Carlos Olivera and James Shade: the clone of a real person who was assigned to the task of an employee with no knowledge of their true nature or identity.
- The reaction of the tank commander of the second Undead army to his orders indicates that this clone may not have been as in charge of Umbrella as he believed or that Wesker was able to countermand his orders since the real Isaacs was being woken up.