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Prime universe
(Capcom's primary storyline)

Amy was the sister of Louise. When the two girls were young, they were involved in a car crash, which killed their mother.

Amy wrote a letter to Louise shortly before the Raccoon City Destruction Incident became noticeable, telling her that she would prefer to go with a third person, "Ed". A castle in her guest room reminded her of Manchester, where she and her sister grew up.[1]

Sources

  1. Resident Evil Outbreak (2003), file: "Guest Memo 2"