BIOHAZARD 2 TV-CM was filmed as part of Capcom's preliminary research into the viability of a live-action Resident Evil film. Wanting a similar quality of make-up; cinematography and directing as would be seen in a feature length film, Capcom financed the short with a considerably larger budget than expected for a film of its length. American film director George A. Romero, famous for his Dead series of Zombie horror films, was given the role of Director.
The main cast consisted of actor Brad Renfro playing the part of Leon S. Kennedy, and Adrienne Frantz as Claire Redfield. Renfro received top billing due to his popularity among Japanese audiences. A number of special effects designers such as Bob Miller and Michael Deak cameoed as Zombies.