Prime universe
(Capcom's primary storyline)

The Bio-Sphere was an underwater facility in the Atlantic Ocean. It was constructed directly underneath the Umbrella Waste Disposal Facility, and was used by a group of bioterrorists led by Morpheus D. Duvall, who sought to hold the United States and China hostage with the t-Virus in exchange for a large sum of money. At some point, the facility experienced a biohazard and its personnel were transformed into zombies. The facility was destroyed when the t-Virus missiles detonated within the Bio-Sphere's missile silo.