Slam - The Blob slams its anchor in a downward motion, sending the player into the dying status.
Swing - The Blob swings its anchor towards the player. If hit, the player instantly goes to the dying status.
Acid Blood - When the massive growth on its back is shot, it will release a stream of acid, stunning players who are near and doing minor to high damage (depending on the difficulty mode).
Grab - The Blob will grab the player off the ground. There is no dodging prompt for this attack. If grabbed, the player has a small time frame of rescue. If not reached, the Guardian will thrust its anchor in an upward motion, impaling the player and resulting in instant death. The grab animation is slightly faster than the Executioner's.
The Blob is unable to run, making them quite easy to escape from. The small eye located on the back of the large tumor is the best weak point. When shot or stabbed, the eye will bleed violently and 'spin'. If you keep shooting the eye, The Blob will easily die (on easier modes, one shot from a magnum will kill The Blob if shot in the eye).
The large tumor growth on its shoulder is another weak point, where several hits from a shotgun will kill or severely injure The Blob. Melee weapons such as the Combat Knife are ineffective, as The Blob will spray acidic blood when injured. However, it is possible to "knife" the Blob.
Continuous damage to the head, or the tumor on the shoulder can take a The Blob down to its knees, leaving it vulnerable to the following melee attacks; Jill: Sweep Kick / High Kick - Chris: Uppercut / Straight. A single shot in the eye on its tumor will always stun The Blob.
During their search of the mansion for Oswell E. Spencer, Chris and Jill, having lost their weapons, resorted to using booby traps against the Blobs. These spiked platforms would drop from above like a moving ceiling, crushing and impaling anything caught beneath them. Though The Blob may be able to stop the platform from crushing them sometimes by using their anchor, at that time the player can either melee them; Jill: Flip Kick - Chris: Haymaker, or throw a Flash Grenade to stop and kill them.