Sapphires appear in several games in the franchise under various names.
- Blue Jewel
- Blue Jewel - A jewel used in the Tiger eye puzzle in Resident Evil
- Blue Jewel - Used in the second music box puzzle in Resident Evil CODE:Veronica
- Blue Jewel - A jewel found in the Raccoon University in Resident Evil Outbreak
- Sapphire
- Sapphire - An item in Resident Evil 3: Nemesis, known as "Blue Jewel" before examining.
- Sapphire (Revelations 2) - An item in Resident Evil: Revelations 2.