"This anti-life form weapon accelerates and fires highly charged particles."
The Charged Particle Rifle is a weapon that can be found in the underwater Missile Silo. It has been created by Umbrella to eliminate any t-Virus and G-VirusB.O.W. and is required for the fight against Morpheus. It has to be charged, and then can be used infinitely and can take out almost any B.O.W. in a single shot. After the first form of Morpheus the rifle loses charge and cannot be reused.
This weapon can be obtained after defeating the game in Hard mode.
Even if a player has it from the beginning, It wont do anything to Morpheus, just like a standard fire arm.