(Covers information from Anderson's universe)
Chris Redfield is a survivor of the Global T-Virus pandemic and worked for a military unit for a while before the outbreak. He reunites with his sister Claire Redfield, who was said to be searching for him.
During the height of the Global T-Virus pandemic, Chris fought alongside a unit of soldiers from the United States Army, which were deployed to guard the Citadel Correctional Facility in Los Angeles. The military intended to use the prison as a stronghold and a base of operations. They intended to evacuate the prisoners, but as the situation at the prison began to deteriorate, the military released the prisoners to aid them in the fight against the growing numbers of undead.
When the prison was deemed expendable, the military was ordered to pull out. In the confusion of their evacuation, Chris was jumped by prisoners and left to rot in a cell somewhere near cell block-B. At an unknown point in time, six Los Angeles survivors (Luther West, Bennett, Angel Ortiz, Crystal Waters, Wendell and Kim Yong) found their way into the abandoned prison and created a safe haven for themselves.
When they discovered Chris, he was dressed in prison garbs, and their immediate reaction was mistrust. They left him locked up in the cell and kept a rotating watch on him. Privy to the structure of the prison, Chris attempts to convince them that he knows a way out of the prison as things get worse, but Luther intends to keep him imprisoned until the arrival of Janus Prospero and his sister Claire.
After Janus releases him, he is reunited with his amnesiac sister who doesn't remember him. With Janus's help, he devises a plan of escape, leading her and Crystal down underneath the flooded levels of the prison below to stock up on defensive weapons and firearms located in the armory. During the escape, survivors are picked off by undead and a mutated zombie.
In the end, only he, Claire and Janus are left. When they reach Arcadia, he fights side-by-side with Claire and Janus against Albert Wesker. Both Chris and Claire are easily defeated by Wesker and trapped in stasis pods. Chris is desperate to reach his sister as the pods descend underneath the floor of the throne room.
Finally, Wesker is defeated by Janus with the help of K-Mart, and Janus releases Chris and Claire. Wesker is not dead despite Janus blowing out the top of his head with a shotgun. Claire and Chris unload their pistols into him and seal him inside the throne room with Bennett (one of the survivors from the Citadel prison). Bennett haggles to be released over the intercom and irritates Chris so much that he shoots out the intercom to silence him.
Wesker escapes, but his helicopter is destroyed with a bomb planted on-board by Janus. Chris witnesses Janus broadcasting a message of hope for survivors across the globe as a massive Umbrella force led by Jill Valentine converges on the ship.
The Final Chapter
To be added
Appearance and wardrobe
Resident Evil: Afterlife
Chris wears a grey bodysuit, black gloves, black utility belt, and black leather boots.
- According to Milla Jovovich, Wentworth Miller will not reprise his role as Chris in Resident Evil: Retribution. When asked, Milla states that Chris, Claire and K-Mart have been captured by Umbrella, explaining their absence in the film.
- Wentworth Miller jokingly admits he was nervous about his character Chris Redfield being similar to Michael Scoffield of Prison break when his first lines were in a prison and his first lines are "I know a way out of here".
- Chris's role of being framed as a killer and wrongly imprisoned is similar to Billy Coen from Resident Evil Zero.
- Chris appeared to have no idea who Wesker was in the film, suggesting that they never met in the movie universe, unlike their game counterparts. Also, Chris was not a STARS member, so probably he haven't met Jill in the movie universe too.