Colmillos are Plaga-infested wolves in Resident Evil 4. The name means "Fangs" in Spanish. They are notable in that each must see you before it will attack (though if a Plaga emerges, the Plaga itself will attack you).
Colmillos first appear if Leon attempts to re-cross the lake after slaying Del Lago. A pack of three of these creatures awaits him on the opposite shore. Later on, near the Village's chapel, another pack is encountered which must be dealt with in order to continue. Ramon Salazar also keeps a selection of these vicious creatures in his maze garden, calling them his pets, where they will attempt to ambush the player while exploring the Maze.