El Gigante must be defeated by doing enough damage to their Plaga. This will sprout out of their backs and the monster will fall to its knees after it has taken a set amount of damage. They will only stay down for a set amount of time.
When their Plagas are exposed, the player can opt to use the command prompt "CLIMB" to climb onto their backs and begin slashing at the Plaga with the character's knife via quick time event involving rapidly pressing one of the face buttons. The player will be given a set amount of time to inflict damage. If the player is too slow or presses the wrong attack button during this action, they will be thrown from El Gigante's back and the player lose their chance to inflict any more damage. The player can also simply shoot at the Plaga - however, it will retreat after set amount of damage (as opposed to time).
Once the Plaga has returned into their bodies and the process must be repeated. All drop 15,000₧ when defeated in the main game and the one in Separate Ways drops 10,000₧.
During the encounter with the first one in the main game, if Leon helps the dog that was stuck in a bear trap near the beginning of the game, it will come and help him fight El Gigante by distracting it from attacking him. But in Professional Mode, the dog is useless. The El Gigante here can also use the three trees in the area to use for the "Large Tree Swing" attack. The three huts in the same area also contain items, but can be destroyed by the enemy if it comes in contact with them in any way. If destroyed, the items inside disappear.
During the encounters at the Road below the cliff as Leon and Ada, the player can shoot the suspended boulders to either drop onto them (thereby reducing their health) or block their path. El Gigante will need to pause to attack the boulder and break it to continue pursuing the player.
During the encounter at the Furnace in the main game, the Gigantes will use the "Scaffold Swinging" move if the player is standing on the scaffolding. The player can also use the switch in the area to open up a lava pit in the middle of the floor. If they cause one to fall into the lava, it will sink for a while. During this time it may use the "Fellow Traveler" move. The other Gigante will always walk around the lava pit. If the player does kill one of them via the lava pit, it does not drop any money. However, there is a bug in the GameCube versions which causes re-entering the room to spawn the money on top of the closed pit.
El Gigante is capable of twelve combat moves in Resident Evil 4. All but three of these deal 800 points in damage.
Note: All names are provided by the Biohazard 4 Kaitai Shinsho guide.
|Punch||800||El Gigante delivers a powerful punch that knocks itself to the ground.|
|Hammer Punch (ハンマーパンチ Hanmā panchi )||800||El Gigante puts both arms together and throws itself to the ground in a powerful punch designed to crush.|
|Uppercut (アッパーカット Appākatto )||800|
|Hook (フック Fukku )||800||El Gigante swings its arm around quickly to knock over its opponent.|
|Kick||400||El Gigante tries to kick an opponent.|
|Trample||800||El Gigante tries to crush an opponent under its foot.|
|Grab (つかみ Tsukami )||800||El Gigante grasps hold of an enemy and attempts to crush it.|
|Throwing grab (つかみ投げ Tsukami nage )||800||A variant of the above where El Gigante instead throws the opponent to the ground.|
|Tackle (タックル Takkuru )||800||El Gigante performs a Rugby tackle, where he storms at his opponent ready to ram it with his head and shoulder.|
|Large tree swing (大木振りまわし Taiboku furimawashi )||800||El Gigante lifts a tree trunk from the ground and swings it at an opponent.|
|Throwing rocks (岩石を投げ Ganseki o nage )||800||A boulder is picked up and thrown at a target.|
|Scaffold Swinging (足場揺らし)||800||El Gigante will throttle scaffolding if someone is using them.|
|Fall||Death||About to die, El Gigante may try to crush its opponent.|
|"Fellow traveler" (道連れ Michidzure )||Death||Falling into a pool of molten metal, El Gigante may try to take its opponent with it.|
|Chapter 2-1||Quarry||Normal-type (1000 hp)||A cutscene will play to introduce the monster and the exits will be sealed off. The player must defeat this one in order to move on. If the player helped the Wolf in the very first chapter it will return to help. This one dies via cutscene and does not use the "Fall" move.|
|Chapter 2-3||Road below the cliff||Normal-type (1000 hp)||This encounter is optional and if the player faces the enemy, they do not have to defeat it to progress.|
|Chapter 4-2||Furnace||Normal-type (1000 hp)
Grazed-type (1000 hp)
|Two different Gigantes appear in this map, a Normal and Grazed type, the latter wearing a mask to cover its mouth and metallic armor that provides some protection from gunshots. The zip-line on top of the scaffolding and lava pit trap door are here. These ones will be able to use the "Scaffold Swinging" and "Fellow traveller" moves.|
|Separate Ways Chapter 2||Quarry||Will be encountered but player can simply run away from it.|
The only weak point on El Gigante is the accordingly overgrown Plaga attached to its spine. When the Plaga is destroyed, so is El Gigante.
Using the command prompt (3 successful attacks, more specifically) will eventually kill El Gigante. It takes ~65 knife slashes to the legs or nether regions in order for the Plaga to appear from the back of El Gigante. After 130 successful slashes and two very quick knife sequences, El Gigante will die. If the player is fast enough with the button prompts, then it is possible to kill El Gigante in just two knife sequences – even on Professional mode.
One does not however have to respond to the action and can instead shoot the Plaga with a powerful weapon. Likewise, a well placed shot from a Rocket Launcher can also instantly kill an El Gigante.
A startlingly efficient way of dealing with El Gigante is to fire three mine darts from the Mine Thrower (without the EX heat-seeking upgrade) in rapid succession at the exposed Plaga: the Plaga will then retreat into the thoracic cavity and the mines will detonate, killing the monster instantly.
- Koichi Hamamura, ed (2006) (in Japanese). biohazard4 kaitaishinsho revised edition. Famitsu. ISBN 4-7577-2638-4.