Gas barrels are featured in a number of Resident Evil games, and are used as explosives to kill or disable a larger group of enemies. The first appearance is in Resident Evil 3: Nemesis, where they were used against swarms of enemies, and were even used by Mikhail Victor in one possible scene. Claire Redfield uses these barrels to bring down a security unit in the opening cutscene to Resident Evil CODE:Veronica. In Resident Evil 4, 5 and the Chronicles titles they are used significantly. The gas barrels also make an appearance in Resident Evil: Operation Raccoon City and Resident Evil 6.  In The Mercenaries 3D two or more gas barrels are featured in each level.

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