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Globsters appear as an amorphous blob with pinkish skin and a large, toothy mouth on their underside. Despite the fact that they are created from humans, nothing resembling a human is left. They have no discernible eyes, ears, nose, arms or legs. They move on land by undulating their "body," albeit rather slowly. Underwater, however, they move much quicker and more gracefully. They are capable of swimming faster than a human, as seen when the player is in the submerged sections of the Queen Dido.
Globsters take additional damage when shot in their vulnerable mouth tissue. They expose their mouths while moving and attacking. Underwater, they are deadly. They will instantly kill any player that is in their sight by swallowing them.