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The Guardian of Insanity is an Infected card in the Resident Evil: The Deck Building Game, making its first appearance as part of the "Alliance" expansion deck. It is based on the "Blob" enemy, which was featured in the Lost in Nightmares scenario of Resident Evil 5: Gold Edition.
The Guardian of Insanity has a Health of 30, and can deal 20 Damage. This makes it one of the weaker Infected cards in the Alliance deck. Once this card is revealed, however, its special effect is to inflict an even 10 Damage on all Character cards.
This effect is similar to that of the Nemesis card from the base set, though weaker. The Guardian of Insanity is worth 2 Decorations.