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"Custom made .50 caliber ammo."
— Inventory description

Handcannon Ammo is an ammunition type found in Resident Evil 4. These are .50 caliber bullets used exclusively by the Handcannon, and will only appear from breakables and enemies' corpses. Handcannon Ammo will only spawn if the Handcannon is present in Leon's inventory.

The ammo becomes redundant once the Handcannon is fully upgraded, as the weapon will then have infinite ammo.

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