Jason Isaacs is a British actor who appeared in the 2002 film, Resident Evil. The character of Dr. Isaacs was named after him.
Isaacs narrated the opening sequence of the film, and makes an uncredited cameo in the end as an Umbrella researcher. According to the commentrary on the original Resident Evil movie both the producer Jeremy Bolt and director Paul W.S. Anderson expressed concern over whether they'd paid Issacs for any of the narration work he'd done.