This easter egg (of sorts) is shown between the ending credits of Resident Evil 4 and the Hunnigan transmission epilogue. It reads:
When reloading the Chicago Typewriter whiled in the Gangster costume, Leon will perform a special animation. If the player performs a few more reloads in quick succession, Leon will perform a different animation of him tossing and catching his hat.
If you walk up to Saddler's throne, it has a " ? ". If you click on it Leon will take a seat in the chair and rest his head upon his knuckles with his legs crossed for a few seconds.
- Barricaded in the cottage surrounded by villagers in Chapter 2-2, if you shoot Louis enough, a cutscene will trigger where he kills Leon.
- The Killer7 magnum is a reference to another Capcom by the same name. The character Kaede Smith has an AMT Hardballer that looks similar to the Killer7 magnum.
- Let Ashley stand somewhere and jump down. After that aim upwards to see, what is under her skirt. She will respond by holding her skirt and saying "You pervert!" or "Hey, what are you looking at?". Works only with the original costume, because the other two are with trousers.
Don't shoot the lake!!
- If Leon shoots the water repeatedly while standing on the wooden pier near the boat before proceeding to fight Del Lago. He will surprise attack Leon and swallow him whole.