It has a base firepower of 1500, a firing rate of 0.60, a capacity of 6, and 3 customization slots. The reload time with the Python takes quite some time, longer than any other weapon in the main game. It is available to Jill in Episode 7-1 in a locked room between the dining hall and the library, requiring a Veltro Keycard to be opened. It is also available during Episode 9-1. It can be found by Keith in the Valkoinen Mokki warehouse (Casual and Normal difficulties only).
In Raid mode, the Python is usually a very powerful weapon with all of its other base stats very low. All of the weapon's stats, in the campaign and Raid mode, can be upgraded with their respective parts. Note that certain characters (most notably Lady Hunk) can reload the magnum quicker than others. The maxium slot for the Python is 5, and it will have at least a green name or better (untagged) when it drops with maximum slots. Its rare tag is called the "Serpent".
The Colt Python also appears in the ff. games:
- Resident Evil: Colt Python
- Resident Evil CODE:Veronica: Magnum (CODE: Veronica)
- Resident Evil Revelations: Pale Rider