Main Street is a major road in Raccoon City. Main Street was a central traffic route leading through the heart of Raccoon City. It was here that some surviving officers of the Raccoon Police Department were killed while attempting to plant a bomb to wipe out a Zombie infestation. Survivors later reassembled the detonator and set off the bomb.
Later, Rodriguez set his helicopter down on the ruins of Main Street, and a final battle with a Renegade Tyrant was also fought in the wreckage.