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Master Key may refer to any of the following:
- "Master Key" - a key teim in Resident Evil found on Wesker's body in the original-iterations
- "Master Key" - a key item in Resident Evil 2 that opens up any remaining locked doors in the laboratory.
- "Master Key" - a key item in Resident Evil Survivor.
- "Master Key" - an item file in Resident Evil: The Darkside Chronicles.