Matilda is the name of a weapon featured in a number of games:
- Matilda (RE4) - The burst-firing handgun featured in Resident Evil 4.
- Matilda (Umbrella Chronicles) - HUNK's personal handgun.
- Matilda (Operation Raccoon City) - The Resident Evil: Operation Raccoon City iteration of the above.
- Matilda (RE2 remake) - One of Leon's handguns in Resident Evil 2's remake.