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She is also known for playing Ana Lucia Cortez on Lost, as well as Leticia "Letty" Ortiz in The Fast and the Furious franchise. She also had a main role in Avatar, which has become the highest-grossing movie ever and her most successful film to date.
She returned to the Resident Evil franchise in its Retribution installment, playing three separate characters, all of whom being clones of her Rain character from the first film.