(Capcom's primary storyline)
Nancy was one of the Tall Oaks survivors during the Tall Oaks bioterror incident. She and her boyfriend Peter, along with a Rookie cop, are saved by Leon S. Kennedy and Helena Harper at a gas station. She appeared to be terrified by the horrific events, often crying and repeatedly begging Peter to help her. The group later sought shelter inside of a gunshop, where they defended it from the undead. In the midst of the fight, Peter's gun jams and he forcefully steals his girlfriend's firearm from her and deserts the group. He is shortly afterward killed by a Bloodshot outside of the gunshop. Nancy appeared to be far more concerned for Peter than he was for her, becoming distressed and screaming his name when was killed.
The group eventually get to the upstairs of the gun shop, where they meet the owner and a Japanese man, where they all hold off for a bus to come to take them all to Tall Oaks Church, and to safety. After getting pushed back all the way to the roof, the survivors hold off till the bus comes, where they all make it downstairs and into the bus. The bus becomes stalled by a Whopper, but they eventually make it out of the city alive, with the exception of the gun store owner and the Japanese man, who were killed in the process.
Unfortunately, Nancy and the rookie police officer are dragged out of the bus by zombies and killed, shortly after the bus crashes near a cliff edge on the way to Tall Oaks Church.
- A woman in the Church mentions Nancy, while praying. She asks "God to watch over [her] Nancy", further stating that she "[doesn't] trust he'll take care of her." The woman's relation to Nancy is unclear, although she can be easily assumed to be her mother. The man the woman is referring to seems to be Peter, reiterating that Peter and Nancy had a very unequal relationship and that Peter didn't seem to care much about her.
- It is interesting to note that both Nancy and the Police officer pay a homage to Leon and Claire Redfield during their fight for survival back in Raccoon City. The officer whom states that it was his first day on the job (meaning he was a rookie cop like Leon), whilst the Nancy was a typical female civilian attempting to survive the outbreak (as Claire was). Unfortunately, neither of them survive the outbreak.