The Nemesis is characterized by its relentlessness, strength, sheer stamina, and comparatively high intellect. Unlike the various Tyrant models before it, the Nemesis shows it is capable of employing weaponry and firearms to achieve its objectives. It demonstrates rational thinking abilities, shooting down a rescue helicopter in order to trap Jill Valentine. It can even be heard speaking at times (though its only utterance is "S.T.A.R.S."). Unlike the other Tyrant models, the Nemesis had no mutated claws to attack its targets, relying instead on its sheer power, rocket launcher, and tentacles.
The Nemesis' primary objective was to eliminate the remaining S.T.A.R.S. members, causing it to ignore all other potential targets when a S.T.A.R.S. member is present or nearby. It makes exceptions for direct threats to it, and obstacles to its target. Like the Tyrants before it, the Nemesis boasts an enormously powerful physique, demonstrating the ability to break through most obstacles, outrun any human, and leap incredible heights. Besides T.A.L.O.S., Nemesis is the most resilient B.O.W. ever created by the Umbrella Corporation, easily withstanding attacks from small-arms weaponry and suffering only incapacitation as a result of explosives. Only the largest industrial-grade weaponry can cause it any notable damage. However, it also appeared to be somewhat unstable; after several unsuccessful attempts to kill Jill Valentine and suffering a significant amount of damage, the Nemesis underwent an uncontrolled mutation, eventually growing into a grotesque, random mutation after consuming organic material from a deceased fellow tyrant. This would arguably be perhaps one of the most if not the most drastic change displayed by a B.O.W infected with the T-virus. "G" is the only B.O.W. with mutational properties matching those of the Nemesis.
The Nemesis possesses a network of tentacles that cover its body; powerful enough to tear through a human body, and capable of infecting victims with the T-Virus. It is also armed with a special Rocket Launcher that is used to target vehicles and potential victims. This rocket launcher was modified specifically for the Nemesis, and was too heavy for a human to carry. Its black trench coat functions as a power limiter and is bullet/explosion-proof.
The Nemesis does not possess any true weakness, aside from the potential for uncontrolled mutation, and is even capable of surviving the disposal chemicals used at the Dead Factory for waste processing. However, the damage it sustained here made it incapable of completing its mission, having lost its intelligence and mobility.