Neptunes are noticeably larger in the REmake than in the original. They are also much more powerful, being able to instantly kill the players by eating them in the Resident Evil remake and Resident Evil Outbreak, though with correct timing, it is possible for the player to evade all of their attacks.
In the 2002 Resident Evil remake, the larger Neptune has an HP value of 4000, with the smaller ones at 1000 each. This is in relation to Chris and Jill's 1400 and 960, respectively. In Resident Evil Outbreak, the Neptunes' HP values vary significantly depending on the difficulty level. EASY has them at 300-450; NORMAL at 550-1000; HARD at 800-1400, and VERY HARD at 800-2000 HP.
The Neptunes are capable of only two unique combat moves in 2002's Resident Evil.
Note: All names are provided by the biohazard Kaitai Shinsho guide.
| Move|| Damage|| Description/notes|
|Jump biting (飛びつきかみつき Tobitsuki kamitsuki )||Small sharks: 300|
Large shark: Instant death
|Leg biting (足かみつき ashi kamitsuki )||90x5|
|Move||Damage (by difficulty)||Description/notes|
|Eat||Instant Death||Instant Death||Instant Death||Instant Death|
Weapon guide (remake)
Note: All stats are provided by the biohazard Kaitai Shinsho guide.
|Weapon||Damage||Number of ammunition/uses|
|Survival Knife (Chris's)||151||7-27|
|Survival Knife (Jill's)||91||11-44|
|Handgun||180 (Critical Hit: 400)||5-23|
|Samurai Edge||300 (Critical Hit: 400)||3-14|
|Shotgun||Close range: 580|
Mid-wide range: 150
|Grenade Launcher (Grenade)||Direct hit: 500|
|Grenade Launcher (Acid)||Direct hit: 500|
|Grenade Launcher (Explosive)||Direct hit: 500|
|Self Defense Gun||9999||1|
|Barry's 44 Magnum||9999||1|
|Flamethrower||style="background: #000; color: grey; vertical-align: middle; text-align: center; " class="table-na" | N/A||style="background: #000; color: grey; vertical-align: middle; text-align: center; " class="table-na" | N/A|
|Infinite Rocket Launcher||Direct hit: 9999|
Resident Evil (1996)
In the original Resident Evil, the Neptunes can be found in the basement of the Guardhouse, where a water tank rupture has released them. As the water is shallow, these small fish (in this iteration) can only attack the legs of humans. They can be easily avoided by using the classic zigzag maneuver to the nearest exit.
Resident Evil (2002)
In the remake, the basement has been replaced with an independent aquatic laboratory. It is here that the mother Neptune will attack her prey from below in an instant-death attack (pictured: right). If Richard Aiken is saved from poison during Chris' scenario, it is here that he will be killed by the mother, serving as a message to the player - don't let her catch you. Whichever character you play is, the play is the same - run along the ring to the next doorway. The tank will begin to shake (and your GameCube pad will vibrate) when the mother approaches.
In Resident Evil Outbreak, the Neptunes will be encountered along the riverside outside Raccoon University. The only place where the creatures can be encountered - the pier - can be avoided, altogether, it should be noted. In this game, they will jump at the player to push them off the pier where, if the player does not swim back in time, they will be consumed.
The Neptune appears in two instances during Resident Evil: The Umbrella Chronicles. Both iterations, being played in an on-rails shooter, are predetermined and will involve the sharks swimming around before jumping at the player. In their second appearance - Umbrella's End 2 - quicktime options will be given to dodge the attack; the Neptune will simply jump over the walkway and into the water on the other side.