New York is a US state based along the east coast.
In the Anderson universe, the state was hit by the Global T-Virus pandemic. Most, if not all, of its population was killed off or infected over the course of five years after the Raccoon City Incident in 2002; and proceeding the events in the city of Las Vegas in Nevada. New York was used by Umbrella as a component of the Umbrella Prime facility to serve as a simulation for controlled biohazardous outbreaks in urban environments. Given that the simulated outbreak in New York involved the huge and hideous Axemen, it is possible that they were involved in the real thing.
In the Perry universe, New York was the home state of George Trevor and his family, which was about an hours drive from Raccoon City, Pennsylvania.