There have been two separate agreements between Capcom and Nintendo which revolve around the exclusivity of Biohazard titles to Nintendo consoles. The first, known as the "Capcom Five" agreement, made Resident Evil 4 and four other (unrelated) Capcom titles exclusives, while a second agreement was between Shinji Mikami and Nintendo regarding the series, itself.
The Nintendo console market waned during the 32-bit era, with their Nintendo 64 system losing out to Sony's PlayStation. One of the major causes of this was Nintendo's reluctance in opening to third party developers, made worse by their refusal to switch to disk-storage in favour of maintaining a monopoly on the cartridge-manufacturing business. Capcom, which enjoyed a successful relationship with Nintendo in the 1980s with Mega Man, offered its assistance in 2002 by making five new titles that would be exclusive to the GameCube, released the following year. The games where intended to provide a significant boost in Nintendo's revenue:
- P.N.03, a science-fiction shooter, failed to capture a wide audience due to mixed-reviews and criticism of its length and controls.
- Viewtiful Joe, a side-scrolling action game directed by Hideki Kamiya, became the GameCube Game of the Year. However, its sales were not successful enough for Capcom, and they ported the game over to the PlayStation 2 in order to recover.
- Dead Phoenix, a shoot-'em-up, was cancelled in August 2003.
- Killer7, a first-person action-adventure game directed by Shinji Mikami, received mixed reception an poor sales, though went on to achieve a cult following, being ported on to the PlayStation 2.
- Resident Evil 4 became a wide-success, though Capcom again had to port on to the PlayStation 2 in order to avoid experiencing major losses.