The Grenade Launcher appears in Resident Evil: Operation Raccoon City. It must be found in weapon crates in various locations around the city. In certain campaign levels, players much find a Blue Key Card in order to unlock a door to access a room that holds this grenade launcher. In later levels, multiple Grenade launchers can be found in crates. Players cannot spawn at the start of a mission with this grenade launcher, unlike the other grenade launcher.