(Capcom's primary storyline)
A genetically engineered form of the Plaga parasite, Type 2 Plagas were created by Tricell, Inc. It is formed by a sample of the normal Plaga parasite being combined with leech DNA. The original Plagas had to find a way into the host in its egg form and be given time to develop within the host. Unfortunately, this means it takes a great deal of time for an infected host to fall under the parasite's control. This was most notably demonstrated in Leon S. Kennedy, who ruined Osmund Saddler's plan of world domination and saved Ashley Graham despite both of them having been injected with Plagas eggs, which they were eventually able to remove.
Type 2 was developed to eliminate said drawback by maturing much, much faster. Infestation of Type 2 occurs by force-feeding an already mature parasite into the mouth of an unwilling host. In this way, the growth rate was drastically increased and the host was under total control of the Plaga in a matter of seconds, much to Tricell's liking. After being ingested, the host (referred to by the uninfected locals of Kijuju as "Majini", "evil spirits") was then instructed to kill and infest others, but could seemingly go about their everyday business. While the original Plagas required the compliance of the host to completely take over control, this type of Plagas does not require it, instantly turning even unwilling hosts into little more than mindless puppets. Only 2 people who were later infected were seen prior to infection with this particular creature.
Although Type 2 Plagas have been strengthened enough to withstand very strong natural sunlight, flash grenades emit such intense light that exposed Plagas will immediately die if they are in the affected area.
- Hatchling: The majority of Majini are infested by so-called "hatchling" Plagas. The only way they manifest is that on occasion when the host is grappling with a non-infested target, the Plagas will emerge from the host's mouth and attempt to bite down on the victim's head. These forms are the weakest Plagas, because if the host dies, the hatchling is not strong enough to manipulate the body by itself; if the host's head is destroyed, the parasite will emerge from the neck stump, but the Majini will die and disintegrate nonetheless.
- Cephalo: They appear as a long tentacle with a blade on the end that emerges from the neck of the host if the head is destroyed and slashes at the player. Although it has a powerful slam attack, merely being in close proximity to a Cephalo can cause minor damage as it is constantly flailing around, whipping the blade back and forth.
- Kipepeo: Winged parasites that detach themselves from their host and attack independently. They attack with the end of their tail.
- Type 2 Plagas appeared in the film, Resident Evil: Afterlife. However the name Plaga is never mentioned, instead they are just another mutation of the T-virus.
- A further engineered plaga was seen in Eastern Slav Republic during the East Slavic Civil War.