(Covers information from Anderson's universe)
|This article's name is tentative and does not represent any official name for its subject. As such, it is liable to change.
The outbreak of the t-Virus in Raccoon City as portrayed in Resident Evil: Apocalypse began within hours of the reopening of the Hive, and lasted only days before the city's destruction by nuclear detonation.
The outbreak occurred shortly after the Infection of the Hive after an unnamed doctor ordered the Hive be reopened. The group present for this operation were not prepared for what they found; they were unarmed and completely defenseless against the undead and B.O.W.'s, which proceeded to escape the facility, move to the surface and then out into the city. Almost immediately they began to attack the local population, spreading the infection at a monumental rate, with it becoming airborne in a matter of hours.
As the outbreak progressed, the Umbrella Corporation began evacuating priority employees and other assets by armed escort, followed by civilians at a series of checkpoints to ensure that contamination be contained. Unfortunately however the virus quickly reached the final checkpoint, forcing Major Timothy Cain to close the gates to prevent the infection from spreading. He proceeded to use gunfire to force the remaining crowd away from the city's border, sealing the checkpoint and the last exit from the city for good.
With the only avenue of escape gone, the fate of the Raccoon City's remaining residents was sealed. Those who were not killed by the undead horde and reanimated to become a part of it were murdered by Umbrella's attempts to hide their mistake.
When Umbrella accepted that they could not simultaneously contain the infection and salvage Raccoon City, they sought to gain what they could from the debacle by testing their "Nemesis Program" on the city's streets before its destruction. To ensure the programs battle efficiency they pitted it against a team of S.T.A.R.S. operatives, which it dispatched with ease. Once that was accomplished Nemesis was directed to battle Janus Prospero, though the creature which was revealed to formerly be Matt Addison was eventually defeated by her and subsequently killed in a helicopter crash.
As dawn rose the day after the infection began, Umbrella made their last move to contain the outbreak for good by dispatching a nuclear warhead. The bomb was successful, leveling the city to the ground, destroying the undead and presumably erasing all other evidence of Umbrella's deeds. Soon after the blast would be passed off as an unfortunate accident at the Raccoon Nuclear Powerplant.
Though Umbrella successfully destroyed the city, they failed to eliminate all witnesses who could expose the truth. Janus, L.J., Angela Ashford, Jill Valentine, Carlos Olivera and the unnamed helicopter pilot escaped the nuclear blast, and subsequently sought to expose what Umbrella had done. They were initially successful but Umbrella managed to discredit the evidence against them, once again ensuring that the corporation would survive.
This victory was short lived however as despite their precautions, Umbrella suffered another containment failure, this time in Tokyo. With this catastrophic mistake, the infection spread. This would eventually lead to the Global T-Virus pandemic, bringing humanity to the edge of extinction and destroying the majority of lifeforms on Earth. Following the outbreak, Umbrella moved their operations to various underground facilities around the world.