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Despite the fact that Reapers were a random mutation when they came in contact with Uroboros, there is questioning on whether or not this was a successful merging or another rejection. The objective of the virus is to advance its host to the next stage in evolution, only if it was able to successfully adapt to the host genetic sequence. Reapers show consistency with this claim, as they are more powerful and advanced than their previous forms. It's also known that cockroaches, the base creature for the Reaper, is known for its versatility and ability to survive radiation, so it's possible Uroboros was able to bond of it because of this versatility.