Wesker stands by the railings of a large room, overlooking a stealth bomber. Chris and Sheva head up to him and raise their Berettas. "Your plans are finished, Wesker!," Chris shouts.
"There's no way out this time!," Sheva continues. Wesker releases his clutch over the rails.
"Don't you two ever tire of failing in your mission?" Wesker removes his sunglasses. "You've really become quite an inconvenience for me." He suddenly throws his sunglasses at Chris and proceeds to rush at Chris, the latter of whom grabs hold of them, not seeing the trap; he is no longer aiming at Wesker. The man then knocks him to the ground and backflipping Sheva - he then puts his sunglasses back on.
Chris gets up and fires wildly at Wesker, who uses his enhanced agility to dodge every bullet. Chris then charges at him, hoping to throw him to the floor - he fails to move him more than a few feet before Wesker throws him against the railings. Chris fires at him again - this time, Wesker sommersaults his way from the bullets to Sheva, whom he takes hostage to stop Chris firing any more.
"Why are you doing this?," asks Chris, "What do you accomplish by releasing Uroboros?"
"Every day, humans come one step closer to self-destruction. I'm not destroying the world; I'm saving it." Sheva pulls herself out of the headlock, allowing Chris and later herself to fire at Wesker, though they still miss due to Wesker's agility, which allows him to beat back the BSAA operatives one at a time. He then graps hold of both of them, throwing Chis and Sheva over the railings and onto the floor below. The viral serum drops out of Chris' pocket as he hits the floor.
"This guy's lost it!," cries Sheva as she tries to get up. Chris gets up and takes back the sample.
"This may be our only chance!", he claims. Wesker jumps from the railings above, preparing to fight Chris to the death.
Sheva calls out "Do it!"
The ceiling begins to open up as Wesker's bomber begins flight preparations. "Things are getting interesting now, eh Chris? Do you actually think you can defeat me?"
"Either way, I'm not gonna stop until I'm dead!"
"Very well then," chuckles Wesker, "I'll just have to kill you quickly."
The majority of this scene was re-enacted in the climax to Resident Evil: Afterlife, even some dialogues. The main difference is that instead of Sheva it is Claire who is fighting with Chris against Wesker.