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Resident Evil: Afterlife (Music from the Motion Picture) is the fourth score released for the film franchise, composed by the transmedia group tomandandy. The score was released via iTunes September 13, 2010 and will be available on a physical disc September 27, 2010. On December 14, 2010, Tomandandy released a "Deluxe Digital Edition" that featured four new bonus tracks, remixes of preexisting cues and a digital booklet.
The Renholdër Apocalypse Mix of A Perfect Circle's "The Outsider" is featured in both theatrical trailers and TV Spots for the film and is featured during the confrontation with Albert Wesker and the ending of the film.
"Zombie" by the electronic/rock band The Trucks is featured in an UGO.com-exclusive TV Spot for the film.