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Synopsis[]
A Mexican Army team supervised by BSAA Captain Chris Redfield investigates a mansion linked to a B.O.W. smuggling operation, which is infested with zombies infected with a new viral strain. There he finds Glenn Arias, a black market dealer wanted by Interpol, but Arias gets away when the mansion explodes. He is soon joined by one of the BSAA's advisors, Dr. Rebecca Chambers, who begins developing drugs to combat the virus encountered in the mansion. The laboratory is attacked by one of Arias' accomplices at the end of her research, and Chris saves her from infection. Following the attack, they get the attention of DSO agent Leon S. Kennedy. Concluding Arias is involved in an upcoming terrorist attack they head out to New York to find him before it can take place.
Plot[]
Chris Redfield is a BSAA observer to the Mexican Army as a squad of nine (including himself) is sent to the Mexican state of Querétaro to apprehend bio-weapons black market dealer Glenn Arias and rescue his hostages, BSAA agent Cathy White and son Zack. With TRICELL and Neo Umbrella gone, Arias has become one of the BSAA's most significant targets by selling their abandoned weaponry. The squad arrives at a Trevor-style mansion used by Arias for his business. They split up into three man teams to search for Arias. One team is attacked and infected by a zombified Zack when they let their guard down. When Chris' team investigates, one of their number is dragged under a bed and devoured, while the other is bitten and transforms. The squad captain meanwhile becomes concerned at the loss of radio contact with his men and calls for their helicopter to return to evacuate the building. Zombies appear in the room and bite the captain. He orders the two remaining soldiers to escape through a door, but they are torn apart by wires set up as a booby trap. Only Chris escapes the building, having jumped out of a window. He fights Arias, but loses when he is knocked down when shot; though his vest protects him, he is still injured by the impact. Arias reveals that his newly designed virus is capable of distinguishing to the infected who can and cannot be killed, and he and his bodyguards leave unharmed through a cluster of zombies led by Cathy. Chris is saved at the last moment by the army helicopter which picks him up, shooting Cathy dead in the process.
In a flashback, Arias and Sarah have just been married, and a drone strikes their wedding reception. The immediate area is destroyed and the guests are killed. Only Arias survives, while only Sarah's left arm remaining. In present-day New York, Arias looks out to the city from his apartment.
Four months later in Chicago, Illinois, university professor Dr. Rebecca Chambers is working with her assistant, Aaron, to create a functional vaccine to a new virus spreading across the United States. At least twenty attacks have taken place nationwide, though the US government is suppressing information on it to prevent alarm. Due to the incidents taking place seemingly at random, Chambers deduces the attacks are the deliberate cause of an unknown agency rather than the virus' natural spread. In the search for a vaccine, 252 experiments have already been run, and Aaron announces the delivery of over thirty infected bodies to help in the vaccine synthesis. With the doctoral student body out of campus this time of year, Chambers elects Aaron to personally obtain viral samples from the bodies. After he leaves, experiment #252 is registered on the computer system as a success in developing a vaccine, and samples are automatically placed in syringes and put in refrigeration.
As Aaron heads down to the morgue, he spots an opened vent. As he investigates, Arias' bodyguard María knocks him out. The laboratory's main power is cut, resulting in it going into a lockdown state and the shutters going down. María releases an airborne form of the virus into the ventilation system. The laboratory staff are infected and transform into Zombies, save Rebecca, who is able to remain herself though weakened. She leaves her lab and heads to the vaccine synthesis room where she injects herself with the new vaccine in time to prevent zombification. Rebecca leaves the room to find Aaron eating a body on the floor. When he notices her, Rebecca resorts to beating him with a fire extinguisher. She escapes back to her lab as more zombies arrive. Hiding in the lab, another zombie appears, whom she kills through stabbing in the brain with a pair of scissors. María blows up the vaccine synthesis room as Chris and his "Silver Dagger" BSAA team arrive to rescue Rebecca.
At a hotel, Rebecca watches news of viral outbreaks. Per the cover-up policy, the attack in Chicago is reported by ENN as having been an attack by armed terrorists. NEWS F3 reports on a mass murder having taken place in a town outside Ontario, with a viral outbreak at a trailer park described as killing a dozen people. Rebecca adds the incidents to a map of North America as she struggles to find a pattern. Chris enters Rebecca's room and explains his need to find Arias; having learnt that Rebecca's lab was the most advanced in the country, he had rightly decided to meet with her to warn of a potential attack. Due to Arias' bodyguard being in the laboratory, Chris suspects Rebecca's new vaccine to soon be useless as Arias will no doubt modify his bioweapon to no longer be affected by it. Rebecca reveals that the new virus' genome is similar to the Plagas used by Los Iluminados in 2004.
Rebecca and the Silver Daggers head out to Colorado in search of Leon, who had previously fought the Plagas when Los Iluminados abducted President Graham's daughter. They find him to be drunk and uncooperative. Having lost his entire squad to a bombing in Washington, D.C., Leon's drinking problem has surfaced and he wants no part in the fight. Chris tries to convince him otherwise, describing Arias as having escaped a smartbombing by a "certain government" to end his arms dealing, only for him to go into hiding for several years until he was assumed dead. Leon still has no interest, seeing the government as reprehensible if it's idea of counterterrorism policy is to bomb a wedding. Having had enough of their arguing, Rebecca warns them that she now understands Arias' virus has already infected people across North America and is lying dormant until something triggers the transformation.
The restaurant is being spied on by Arias. Intrigued by Rebecca, he orders María to apprehend her. When Rebecca heads to the restroom, she notices blooding leaking out from under a cubicle. Investigating, she finds a young woman dead inside. This is revealed to have been a diversion, and María grabs Rebecca from behind.
Back in the restaurant, a man Leon knows as Patricio runs in. Leon blames him for the death of his unit and calls him a sell-out. Patricio warns him his wife and daughter have been taken hostage in Spain by an arms dealer, and that the surviving members of Los Iluminados are working with him to create a bioweapon to attack the United States. Leon demands information on Arias up front in exchange for helping his family. Just then a van turns up full of soldiers in black armour. Diego follows with a gatling gun and attacks the restaurant, killing a restaurant worker instantly and seriously injuring Patricio, who bleeds out. Chris looks out and finds the attack was just a distraction to kidnap Rebecca. Patricio's phone rings; Leon answers it to find Patricio's wife pleading for news that the hostage deal went through.
Rebecca wakes up in Manhattan, wearing in a wedding dress. She is in a room surrounded by a television screen displaying a pleasant woodland background, with the room itself decorated to resemble an outdoor wedding reception. Arias enters the room and reveals the various boxes on chairs in the reception contain what is left of his friends and family, who he partially revived thanks to the "A-Virus". Rebbecca reveals her research to him, that she has worked out there are three strains to the virus. The first is the "latent" strain which has spread acrosss the midest via the Great Lakes' drinking water. It is non-threatening on its own, save random activations in hosts. It was supposed to only cause zombification when the host is exposed to the "trigger", an airborne strain dispersed in gas clouds. A third strain acts as a vaccine, allowing the infected to avoid transformation. All of this, Arias confirms. Taken by Rebecca's resemblance to Sarah, he proposes to her, threatening to have her infected with the a-Virus and ordered to agree should she turn him down. Rebecca refuses to marry him, so he has her sent away to the lab to be infected.
Leon and Chris are looking through Rebecca's laptop for any information they can find on her location. Leon remembers Patricio's phone, and decides to insert its SD card into the laptop. They find that Arias' agents have assisted in the selling off A-GUA-G brand mineral water in New York, which contains the latent virus. Once the brand is popular enough, the trigger will be released, ensuring maximised spread of the virus. They also find that there is a contingency in place; Arias' own vaccine can be dispersed over New York to immunise the Zombies and return them control of their bodies.
In New York, Arias calls for the attack to happen immediately across the Great Lakes, having previously scheduled it for the following day. A-GUA-G trucks drive around New York, park at designated spaces and disperse the trigger into the streets, transforming drinkers of their mineral water into zombies. The NYPD is quickly overwhelmed by zombies appearing seemingly at random. The freshly-vaccinated Silver Daggers arrive and receive word that the BSAA and NYPD SWAT are having a hard time countering the attack, with sizable state police reinforcements being three hours away due to handling other attacks.
The team land on the ground, finding the local BSAA only had reserves to supply them with one Gambit and a Ducatti motorcycle. The team splits into two groups (Nadia and DC, and Leon; Chris and Damian) to look for the tankers. Leon throws a grenade at a nearby AGUA truck; with the virus in Rebecca's notes being killed at high temperatures, it is successfully destroyed without risk to nearby people. Arias' agents take notice of the attack, but are quickly taken out by the Silver Daggers. Damian is attacked and killed by Zombie Dogs kept in the back of their van for security. Leon distracts the Zombie Dogs from Chris, and has them chase him in the motorcycle into a highway.
Chris follows Arias to a lab and tries to rescue Rebecca, ignoring his warning that she has thirty minutes before the virus takes over. When Rebecca begins to fall ill during the escape, Chris is forced to return to the lab. He is attacked by Diego and a surgeon, but he succeeds after a brief fight. Chris considers infecting Rebecca with the "Inactive" strain to prevent her becoming a zombie. He gets into a fight with Arias and succeeds by letting him fall down a skyscraper. He is still alive, though severely wounded when Diego finds him. Arias tells him to release the final stage of his infection by removing the safety mechanisms from his body and he obliges. Diego mutates and infects Arias, and they both soon merge and become a tyrant-like creature. Surprisingly enough, Arias still retains his intellect in spite of his transformation. He gets into a fight with Chris and Leon just arrives in time to aid him and distract Arias. Chris then goes and tries to find the vaccine. The Silver Daggers come to Leon's aid and Nadia snipes Arias and damages his shoulder and a part of his face. Arias jumps onto the helicopter and injures her with his retractable claws. Leon gets onto his motorcycle and drives it towards Arias. He jumps off before it rams into Arias and explodes. Chris launches a grenade at Arias' heart, finally killing him. Rebecca is infected with the "Inactive" form of the virus and is no longer ill. The Silver Daggers leave the building in a helicopter intent on dispersing "Inactive" onto the ground below to end the epidemic. María is revealed to have survived.