As Resident Evil 2 was wholly-developed by Tiger Electronics' in-house studio, Tiger was also responsible for the advertisement campaign, which was also used to advertise the console.
Tiger Electronics produced a live-action 30 second trailer to advertise their Resident Evil 2 remake. The plot has a continuingly-decomposing Zombie reporting an assault to the police, identifying the Game.com console as the assailant. The ad ends with an announcer declaring the Game.com to be "the only portable cartridge that plays Resident Evil 2".
In late 1998, Tiger launched the "Game.com Pocket Pro Challenge". Contestants would play Resident Evil 2 on the handheld console and upload their highest scores online using the Tiger Web Link. The player with the highest score would win a U.S. Savings bond valued at $10,000. The contest ended January 15, 1999.