- Main article: outbreak revisited
Not a true scenario, but a tutorial and a means for players of the original Outbreak to learn some of the new gameplay mechanics available in File #2. The locations are lifted directly from areas of Outbreak - such as J's Bar. The tutorial teaches the player the controls of the game by scattered notes found throughout the level.
- Main article: wild things
This scenario takes place around the Raccoon Zoo where Cindy Lennox and the Outbreak survivors await the arrival of an evacuation helicopter, which, unfortunately, crashes.
- Main article: underbelly
Jim Chapman guides the other 3 survivors through the subway in an effort to escape via the train system. This proves harder than it initially seems when it is learned that the subway has been infested by mutated flea-like insects (called Mega Bites).
- Main article: flashback
Alyssa Ashcoft's survivors escape the city and into the Raccoon Forest. However, not all is what it seems as dark tales of murder and savagery involve an abandoned hospital nearby.
- Main article: desperate times
Kevin Ryman's survivors escape to the Police Department. Although defenses seem well, it is only a matter of time before the building is lost.
"end of the road"
- Main article: end of the road
David King's survivors raid an Umbrella facility in need of supplies. But even Umbrella is unable to stop its creations let loose throughout the city. Will the survivors make it out of the city alive before the Sterilization Operation is approved?