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In the Japanese version Steve calls Claire 'Onee-Chan' literally meaning 'Sister" However, it is also a sort of pet name given to older girls one is close to. The localization gave it an oddly literal translation of "Sis", causing confusion in the western markets.
Since the game is a dream that Claire has of the events that she experienced during Resident Evil CODE:Veronica, it's unclear why Nemesis-T Type appears as he did not appear in the game and Claire has never encountered him.