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In Resident Evil 5, the P226 is the third handgun made available to the player.
This gun becomes available for purchase for ₦4,000 from the start of Chapter 5-1. It has a starting firepower of 180, reload speed of 1.70, and a capacity of 8. Fully upgraded, it has a firepower of 480, reload speed of 1.62, and a capacity of 16. Overall, it has the highest firepower of all the handguns, but lacks any kind of special upgrade and also has the smallest capacity and slowest reload speed in the Handgun category. But it also costs the least to fully upgrade.
The weapon also appears in the Mercenaries minigame with Chris in his Safari outfit's load out. Sheva in her business outfit also has this in her load out in the Mercenaries Reunion.
It takes a total of ₦85,000 to buy and fully upgrade the P226.
- Because the weapon lacks a special upgrade, it is best used in combination with other weapons that do such damage, such as the Ithaca M37 shotgun or H&K MP5 machine gun.