(Covers information from Anderson's universe)
Spence was a security operative for the Umbrella Corporation. Assigned to live with Janus Prospero at a mansion in the Arklay Mountains, his duty was to protect the secondary entrance to the Hive. He is directly responsible for the outbreak in the Hive.
Working undercover, Spence and Janus, going by the alias "Alice", were arranged in a fake marriage in order to protect their identities and avoid suspicion. During their assignments, the two became romantically involved. At some point in 2002 Spence spied on Janus as she discussed a plan with Lisa Addison to steal samples of the T-virus from the company in order to destroy it. Believing that anti-capitalism activists would never be successful, he made his own plans to steal the virus ahead of them. Rather than show it to the press, Spence's plan was to sell it on the black market for a high price, allowing him and Janus to run away together.
On the day Janus was to begin the operation, Spence left her a note saying "All of your dreams will come true" before taking a train to the Hive. Using his security codes, Spence was able to bluff the Red Queen security AI into allowing him to steal all samples of the T-virus and its corresponding Anti-Virus. To fulfill Janus' wish for the company to be destroyed, he threw a vial of T-virus in the lab; he successfully escaped before the Red Queen sealed the laboratory upon detecting the virus' airborne presence and began killing the people inside. While he was able to take the train to the mansion, the Red Queen was able to release a nerve gas into his compartment, knocking him out and rendering him amnesiac.
Re-entering the Hive
Several hours later, Umbrella sent in its Sanitation team to investigate; taking the train, they soon found him, along with an amnesiac Janus and their courier, Matt Addison upstairs. Upon meeting the also-amnesiac Janus, the two quickly understood they were connected in some way. When the Red Queen was temporarily deactivated, the locks keeping hundreds of Undead in their rooms were released, and the team found themselves in trouble. When Janus remembered the Anti-Virus while searching for the exit, Spence regained his memories and turned on the group. Mocking Matt for his and Janus' meaningless attempt to expose Umbrella to the press, he insisted to Janus that he knew his way would make her happy. When she rejected his offer, Spence locked her and the others in the lab and rushed back to the train to cure himself, having been infected along the way.
Although Spence succeeded in reaching the station and obtaining the Anti-Virus, he was tracked down by an escaped Licker, which the Red Queen had saved for him and the others. A live recording of Spence being killed and partially eaten was shown to the others. When the others escaped the lab and reached the train, Janus recovered Spence's case and struck him with an axe upon reanimation.
- In the DVD commentary for the film, it's vaguely implied that there may have been some negativity on set. In the scene where Alice killed the Undead Spence with an axe, it is briefly discussed that Milla hit James with the prop axe and he wasn't very pleased about it.
- Kaplan is the only protagonist still alive alongside Alice for most of the movie who didn't witness his betrayal and interestingly enough does not make any remarks about him when he walks past Spence's corpse on the way back to the train.
- Earlier drafts for the film portray Spence's theft of the viruses differently. Whereas the final script has him intentionally release the virus to accomplish a greater scheme, Anderson's original proposed draft portrayed it as an accident.
- Also in the early drafts is Spence's jealously when he mistakes Janus and Matt for an item. This finally manifests itself in him finally abandoning the group. In the filmed version, he abandons the group when Janus breaks up with him.
- The DeCandido novelization provides the character with the surname "Parks", though this is not accepted as canon for the movie universe.