The Spencer Rain (スペンサーレイン号) was an Umbrella owned luxury cruise ship named in honour of Oswell E. Spencer, used as a setting in Resident Evil: Dead Aim  The ship served two purposes, the first consisted in offering top Umbrela officials and celebrities exquisite entertainment; the second, more sinister and main purpose, was conceived to ship Bio Organic Weapons between ports. In 2002 the T-Virus was unleashed upon it by rogue operative Morpheus D. Duvall and his associates, Morpheus planned to use the ship as a missile base, in order to threaten the world with T-Virus filled missiles. His goal was to create a world that he saw fit, based on beauty and thus obliterating 'ugliness'.
In response to the outbreak, US-STRATCOM agent Bruce McGivern boarded the ship to stop Duvall, whilst also running into Chinese operative Fong Ling. Morpheus was killed and the ship was destroyed when it collided with an island.
- Designs for the Spencer Rain were partially inspired by liners run by NYK Cruises, which Production Studio 3 took photographs of. The company is given special thanks in the game credits.
- In Namco ✕ Capcom, a copy of the Spencer Rain appears, replacing the original and covering what happened to it.