Sploders appear to be normal Afflicted that undergo a further mutation that triggers upon the death of the host. After a few seconds, the infected's body becomes covered in pustules that consume the host's upper torso, shaping it into a new form. The new creature lacks a visible head and its stomach has become bloated as a result of the acidic bile stored inside. Physical damage to the body causes this bile to expand until it violently explodes, destroying the host in the process. The bile can blind and injure anyone caught in the vicinity of the explosion.
Like all Afflicted, the Sploder develops a weakness to light. Prolonged exposure will cause the bile to erupt whilst still inside the host and instantly kill it. If eliminated in this method, the Sploder's corpse will not disintegrate.
In the campaign, some Afflicted are scripted to become Sploder and others can happen randomly. In Raid Mode, some Sploder spawn as part of the stage or Afflicted are scripted to turn into them.
When an Afflicted becomes a Sploder, its corpse starts bubbling and growing pustules and it makes a distinct sound. Sploder have a relatively small amount of health. They can only walk towards the player and explode (killing itself) to harm the player. Upon death from taking damage, they will still explode. Visually, Sploder bloat up and expand as they take damage. Moira's Flashlight will cause damage to them quickly.