Four submarines appear in the Resident Evil game series:
- Umbrella submarine - an Umbrella-operated sub appearing in Resident Evil Gaiden.
- Neo Umbrella submarine - a submarine operated by Neo Umbrella in Resident Evil 6.
- "Rescue sub" - Ada's insertion and planned escape method for evacuating the submarine mentioned above.
- HCF submarine - a submarine seen in the port area of the Antarctica facility in Resident Evil CODE:Veronica
- Submarine - a file in Resident Evil 6.