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That's Life is an article in Resident Evil Recollections. It was uploaded on 10 September 2015.
Moira and Claire come across the body of a security guard holding a key during Episode 1 of Resident Evil Revelations 2. When they try to retrieve the key, the body is released from the shackles that were holding it and falls to the floor below, prompting Moira to quip "Well that blows".
Only a daughter of Barry Burton would be able to be that calm in such a situation (although she was pretty flustered up until shortly before).
I'm thinking of inserting the phrase into my own vocabulary some time, it's hard to find a good moment to use it though.