(Capcom's primary storyline)
This unnamed Spanish castle was an enormous fortress and monastery complex in rural Spain. Adjacent to a large lake, it loomed over a nearby village.
The castle was built before or during the time of Salazar, 1st Castellan. The expansive ruins below it were used as a prison for the Plaga parasites to prevent the cult of Los Iluminados from surviving beyond his reign. The ruins were reopened in the 21st century on the orders of Ramon Salazar, 8th Castellan, who had become a member of the revived cult.
Areas of interest include an extensive hedge maze filled with Salazar's "pets," many large towers, including one that houses a gigantic statue of Salazar himself, and an extensive sewer and cave system, housing some of the castellan's pet insects. The castle may have been built near a volcano, as one of the rooms was situated directly above a lava pit.
The Castle begins at Chapter 3-1 and continues until Chapter 4-4. The most common enemies of the castle are the Zealots, the religious cultists of the Los Iluminados. They are armed with flails and occasionally scythes. Further into the castle you will eventually reach the Plaga Mines, where you meet up with some familiar foes. Among the many sub-bosses in the castle include Armadura, Garradors, Cultist Leaders, and Chainsaw Men. Bosses include Salazar's "right hand" Verdugo, twin El Gigantes, and finally Salazar himself.
- In the room where you can find a RPG-7 surrounded by glass, you can also spot a massive painting depicting famous Greek philosophers. This is the "The School of Athens" by the Italian Renaissance artist Raphael.
- In addition, the bedroom where you encounter Ada for the first time also houses the work "Primavera" by Italian Renaissance artist Botticelli.
- In the room where the cage with Garrador is located, a fresco can be seen on the wall - it's "Funerary monument to Sir John Halkwood" by Paolo Uccelo. Commissioned in 1436 for Florence's Basilica di Santa Maria del Fiore
- The Castle is visible from the Skylift and the silhouette can be seen from the island when the player first arrives.
- Apparently, the castle's existence was known by the Umbrella Corporation prior to its fall, as blueprints and schematics for the castle could be seen on the screen just after Albert Wesker returns to his hideout and accessing the Umbrella Archives.
- Hamamura, Koichi, ed (2006) (in Japanese). biohazard4 kaitaishinsho revised edition. Famitsu. ISBN 978-4-7577-2638-3.