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Treasure chests appear throughout the games, and various items can be found inside, ranging from healing items to ammo and even weapons. In later games, they may contain treasures, as well. In Resident Evil 5, opening some treasure chests can also trigger the activation of traps.
In the Mercenaries mini-game of Resident Evil 4 and Resident Evil 5, treasure chests contain a "Bonus Time" hourglass - an item which provides a certain amount of time in which to kill enemies to achieve larger scores.