The T-103 was an improvement over human bio-weapon development, which was spearheaded by the Arklay Laboratory and their T-002 prototype. The T-103 was largely untested in early 1998, and had already spawned several derivatives by July 1998, when the T-002 was destroyed by S.T.A.R.S. Alpha team member Jill Valentine.
The T-103 model proved to Umbrella that the Tyrant class of B.O.W. was commercially viable, in that they could be mass-produced, they were compliant with programming, and they were lethally effective at their tasks. As a result, not only were multiple batches of T-103 Tyrants produced, data from the T-103 was eventually used to enhance future forms of Tyrant. At least four models of Tyrant exist that can be directly connected to the T-103:
Ivan: This model of Tyrant was a T-103 variant specially modified to capitalise upon the human-like appearance of its previous model, enabling them to better blend into humanity whilst still being lethally effective bodyguards. Only 10 Ivan models are known to have ever been created, and at least two of these were assigned to Sergei Vladimir as his bodyguards; this first batch of Ivans were, in fact, created from clones of Sergei Vladimir.
Unidentified Tyrant series: This model is the latest known Tyrant model based on T-103, developed in Eastern Slav Republic lab of president Svetlana Belikova in 2011. This tyrant model is slightly larger than the mass production model, does not have a visible heart in their super form, therefore make it harder to defeat.