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This facility was set up in the late 1960s by Umbrella in secrecy. Built within the underground ruins of the Ndipaya Kingdom, only high-ranking Umbrella researchers and the remaining Ndipaya knew of its existence.
The center was built to study a plant species called the "Stairway of the Sun". This flower, when cultivated in the area, naturally produced the Progenitor virus. The installation of a Laboratory was also due to the flowers not producing Progenitor when taken from their natural habitat.
The facility sent out Progenitor to Umbrella's top research facilities from then on until it was abandoned some time after the Raccoon City Destruction Incident was halted by the Sterilization Operation. After it closed down in 1998, most of the researchers who knew of the facility's existence were eliminated by the Umbrella Corporation in an attempt to cover their tracks.
- Full article: Uroboros Laboratory
The pharmaceutical enterprise, Tricell, under the guidance of Albert Wesker and Excella Gionne, claimed the abandoned facility and began creating their own, further underground. It was here that they further developed the Progenitor Virus and began work on the Uroboros Project. In 2009, the facility was infiltrated by BSAA agents Chris Redfield and Sheva Alomar. They would discover the intentions of Wesker and Gionne as they ventured through the facility. Inside, they found a large revolving elevator, which was surrounded by thousands of capsules housing the test subjects of the Uroboros Project. Also, they encountered numerous creatures including: Licker β, the U-8, Reapers and firearm wielding Majini. They would eventually rescue Jill Valentine from Wesker's control and exit the facility to board the Tanker. Wesker and Excella were soon killed, finally leaving the Umbrella Africa Research Facility closed for good.
- To date, the Umbrella Africa Laboratory is one of the few laboratory settings in the series to not feature a self-destruct mechanism, the others being the Uroboros Laboratory and the Caucasus Laboratory.